TGFB1 CLIA Kit for Human(Homo sapiens) | EIAab.comTGFB1 CLIA Kit for Human(Homo sapiens)

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TGFB1 (Gene name),

Transforming growth factor beta-1 (Protein name ), TGFB1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (2)

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Gene name:

TGFB1(TGFB);

Protein name:

Transforming growth factor beta-1(TGF-beta-1);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

The inactive form consists of a TGFB1 homodimer non-covalently linked to a latency-associated peptide (LAP) homodimer. The inactive complex can contain a latent TGFB1-binding protein. The active form is a homodimer of mature TGFB1; disulfide-linked. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT. Interacts with ASPN.

Function:

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.

Subcellular Location:

Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

390

Sequence:

50:

100:

150:

200:

250:

300:

350:

390:

SAAPCCVPQA | LEPLPIVYYV | GRKPKVEQLS | NMIVRSCKCS |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00019

STRING:

9606.ENSP00000221930

MIM:

131300

UniGene:

Hs.645227

KEGG:

hsa:7040

String:

P01137

SMR:

P01137

Uniprot:

P01137

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ELISA Kit for Human TGF-beta-1

Cat.:

E0124b

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96T

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ELISA Kit for Human TGF-beta-1

Cat.:

E0124h

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96T

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ELISA Kit for Human TGF-beta-1

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E0124m

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96T

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ELISA Kit for Human TGF-beta-1

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E0124p

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96T

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ELISA Kit for Human TGF-beta-1

Cat.:

E0124d

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96T

ELISA Kit for Human TGF-beta-1

Cat.:

E0124c

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96T

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ELISA Kit for Human TGF-beta-1

Cat.:

E0124r

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96T

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CLIA Kit for Human TGF-beta-1

Cat.:

U0124d

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Packing:

96T

CLIA Kit for Human TGF-beta-1

Cat.:

U0124c

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96T

CLIA Kit for Human TGF-beta-1

Cat.:

U0124r

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96T

CLIA Kit for Human TGF-beta-1

Cat.:

U0124m

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human TGF-beta-1

Cat.:

U0124h

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Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human TGF-beta-1

Cat.:

U0124p

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MSDS:

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Packing:

96T

CLIA Kit for Human TGF-beta-1

Cat.:

U0124b

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96T

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Polyclonal Antibody for Human TGF-beta-1

Cat.:

P0124Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human TGF-beta-1

Cat.:

P0124Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human TGF-beta-1

Cat.:

P0124Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human TGF-beta-1

Monoclonal Antibody for Human TGF-beta-1

Protein for Human TGF-beta-1

Cat.:

R0124h

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Packing:

1mg

Purity:

>90%

Protein for Human TGF-beta-1

Cat.:

R0124m

Price:

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Packing:

1mg

Purity:

>90%

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Bystander Me45 Melanoma Cells Increase Damaging Effect in UVC-irradiated Cells"

A Krzywon, M Widel.

From:Photochemistry and Photobiology

[2].

"Simvastatin Attenuates Intestinal Fibrosis Independent of the Anti-Inflammatory Effect by Promoting Fibroblast/Myofibroblast Apoptosis"

Y Abe, M Murano, N Murano, et al.

From:Digestive diseases and sciences

References

1.

"Intron-exon structure of the human transforming growth factor-beta precursor gene."
Derynck R. , Rhee L. , Chen E.Y. , van Tilburg A.
Nucleic Acids Res.15:3188-3189(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells."
Derynck R. , Jarrett J.A. , Chen E.Y. , Eaton D.H. , Bell J.R. , Assoian R.K. , Roberts A.B. , Sporn M.B. , Goeddel D.V.
Nature316:701-705(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS PRO-10 AND PRO-25
3.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Duodenum.
tissue: Eye.
7.

"Cloning and expression of the gene for human transforming growth factor-beta in Escherichia coli."
Urushizaki Y. , Niitsu Y. , Terui T. , Koshida Y. , Mahara K. , Kohgo Y. , Urushizaki I. , Takahashi Y. , Ito H.
Tumor Res.22:41-55(1987)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 279-390
tissue: Carcinoma.
8.

"Recombinant human transforming growth factor-beta 1: expression by Chinese hamster ovary cells, isolation, and characterization."
Bourdrel L. , Lin C.-H. , Lauren S.L. , Elmore R.H. , Sugarman B.J. , Hu S. , Westcott K.R.
Protein Expr. Purif.4:130-140(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 279-329
tissue: Urinary bladder carcinoma.
9.

"Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines."
Massague J. , Like B.
J. Biol. Chem.260:2636-2645(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 279-301
10.

"Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization."
Miyazono K. , Hellman U. , Wernstedt C. , Heldin C.H.
J. Biol. Chem.263:6407-6415(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-42 AND 279-290;CHARACTERIZATION
11.

"Latent transforming growth factor-beta: structural features and mechanisms of activation."
Munger J.S. , Harpel J.G. , Gleizes P.E. , Mazzieri R. , Nunes I. , Rifkin D.B.
Kidney Int.51:1376-1382(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
12.

"Dermatopontin interacts with transforming growth factor beta and enhances its biological activity."
Okamoto O. , Fujiwara S. , Abe M. , Sato Y.
Biochem. J.337:537-541(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DPT
13.

"Differential gene expression of cultured human osteoblasts."
Shur I. , Lokiec F. , Bleiberg I. , Benayahu D.
J. Cell. Biochem.83:547-553(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
14.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-82
tissue: Plasma.
15.

"Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes."
Finnson K.W. , Tam B.Y.Y. , Liu K. , Marcoux A. , Lepage P. , Roy S. , Bizet A.A. , Philip A.
FASEB J.20:1525-1527(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD109
16.

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-82
tissue: Platelet.
17.

"Mechanisms for asporin function and regulation in articular cartilage."
Nakajima M. , Kizawa H. , Saitoh M. , Kou I. , Miyazono K. , Ikegawa S.
J. Biol. Chem.282:32185-32192(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH ASPN
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Transforming growth factor beta 1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells."
Archer S.J. , Bax A. , Roberts A.B. , Sporn M.B. , Ogawa Y. , Piez K.A. , Weatherbee J.A. , Tsang M.L.-S. , Lucas R. , Zheng B.-L. , Wenker J. , Torchia D.A.
Biochemistry32:1152-1163(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 279-390
20.

"Transforming growth factor beta 1: secondary structure as determined by heteronuclear magnetic resonance spectroscopy."
Archer S.J. , Bax A. , Roberts A.B. , Sporn M.B. , Ogawa Y. , Piez K.A. , Weatherbee J.A. , Tsang M.L.-S. , Lucas R. , Zheng B.-L. , Wenker J. , Torchia D.A.
Biochemistry32:1164-1171(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 279-390
21.

"Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2."
Hinck A.P. , Archer S.J. , Qian S.W. , Roberts A.B. , Sporn M.B. , Weatherbee J.A. , Tsang M.L.-S. , Lucas R. , Zheng B.-L. , Wenker J. , Torchia D.A.
Biochemistry35:8517-8534(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 279-390
22.

"Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women."
Yamada Y. , Miyauchi A. , Goto J. , Takagi Y. , Okuizumi H. , Kanematsu M. , Hase M. , Takai H. , Harada A. , Ikeda K.
J. Bone Miner. Res.13:1569-1576(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PRO-10
23.

"Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease."
Kinoshita A. , Saito T. , Tomita H. , Makita Y. , Yoshida K. , Ghadami M. , Yamada K. , Kondo S. , Ikegawa S. , Nishimura G. , Fukushima Y. , Nakagomi T. , Saito H. , Sugimoto T. , Kamegaya M. , Hisa K. , Murray J.C. , Taniguchi N. , more...
Nat. Genet.26:19-20(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CE CYS-218; HIS-218 AND ARG-225
24.

"Mutations in the gene encoding the latency-associated peptide of TGF-beta 1 cause Camurati-Engelmann disease."
Janssens K. , Gershoni-Baruch R. , Guanabens N. , Migone N. , Ralston S. , Bonduelle M. , Lissens W. , Van Maldergem L. , Vanhoenacker F. , Verbruggen L. , Van Hul W.
Nat. Genet.26:273-275(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CE HIS-81; CYS-218 AND ARG-225
25.

"A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-beta1 (TGF-beta1) and its signaling pathway."
Watanabe Y. , Kinoshita A. , Yamada T. , Ohta T. , Kishino T. , Matsumoto N. , Ishikawa M. , Niikawa N. , Yoshiura K.
J. Hum. Genet.47:478-483(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PRO-10
26.

"Transforming growth factor-beta-1 mutations in Camurati-Engelmann disease lead to increased signaling by altering either activation or secretion of the mutant protein."
Janssens K. , ten Dijke P. , Ralston S.H. , Bergmann C. , Van Hul W.
J. Biol. Chem.278:7718-7724(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS CE HIS-81; CYS-218; ASP-222 AND ARG-225
27.

"A mutation affecting the latency-associated peptide of TGFbeta1 in Camurati-Engelmann disease enhances osteoclast formation in vitro."
McGowan N.W. , MacPherson H. , Janssens K. , Van Hul W. , Frith J.C. , Fraser W.D. , Ralston S.H. , Helfrich M.H.
J. Clin. Endocrinol. Metab.88:3321-3326(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT CE CYS-218
28.

"TGFB1 mutations in four new families with Camurati-Engelmann disease: confirmation of independently arising LAP-domain-specific mutations."
Kinoshita A. , Fukumaki Y. , Shirahama S. , Miyahara A. , Nishimura G. , Haga N. , Namba A. , Ueda H. , Hayashi H. , Ikegawa S. , Seidel J. , Niikawa N. , Yoshiura K.
Am. J. Med. Genet.127A:104-107(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CE GLY-223 AND ARG-223

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